Linaclotide Powder

Linaclotide Peptide Description
Linaclotide powder, a polypeptide containing 14 amino acids, is China's first commercially available agonist for intestinal epithelial cells guanylate cyclase C(GC-C). Its mechanism of action is different from that of existing IBS-C therapeutics, and it can effectively improve patients' symptoms. It can treat constipated irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC). API linaclotide is a guanylate cyclase C agonist that binds to intestinal GC-C, resulting in elevated intracellular and cGMP concentrations. Increased intracellular cGMP can stimulate intestinal fluid secretion, accelerate gastrointestinal migration, and thus increase the frequency of defecation. Increased levels of extracellular cGMP can decrease the sensitivity of pain-sensing nerves and reduce intestinal pain. It is the first drug to treat constipation with this mechanism of action. In addition, it is an oligopeptide agonist for guanylate cyclase 2C and remains in the gastrointestinal tract after oral administration. Its degradation products are mainly distributed in the gastrointestinal tract, so it rarely causes kidney and liver damage, and its efficacy is unaffected by liver and kidney function. Linaclotide rarely causes kidney and liver damage daily, so if you are interested in wholesale linaclotide, please get in touch with Xi'an' Sonwu.

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Where To Buy Linaclotide
Xi'an Sonwu Biotech Co. ltd. is a manufacturer and distributor with over ten years of experience. It has extensive and stable cooperation with countries worldwide in the Americas, Asia, Europe, and Oceania. Xi'an Sonwu has always insisted on product quality first. Serving every customer well and satisfying every customer is Xi'an Sonwu's pursuit. Xi'an Sonwu strictly controls every step, from selecting raw materials and pursuing high-quality products from all aspects, such as material selection, manufacturing, sample testing, and personnel professionalism. In addition, Xi'an Sonwu strives to handle every detail to minimize costs and allow customers to get products with high-cost performance. Based on these, customers have given good feedback on the product. So if you need API linaclotide, please contact Xi'an Sonwu.
Xi'an Sonwu entirely makes specific products quality and supplies the samples. Here is the quantity.

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What Is Linaclotide Used For
1. Internal organ's analgesic effect and secretion

Linaclotide powder can increase the secretion of chloride and bicarbonate in the small intestinal cavity and ultimately increase the secretion of small intestinal fluid, increase the rate of colon transfers, etc., to achieve the effects of urination, alleviating abdominal distension, etc. road. If the intestine is not clean, it will affect the intestinal mucosa's observation so that the colonoscopy can get effective results. Linaclotide can help patients to defecate and clean the intestines, so it can also be used as a drug before a colonoscopy. Linaclotide and its active metabolites activate the cystic fibrosis cross-membrane transmission adjustment factor (CFTR). CGMP intracellular CGMP can increase the secretion of chloride and bicarbonate in small intestinal cavities and eventually increase the secretion of small intestinal fluid and colon.

2. Treatment of constipation intestinal syndrome and alleviating the disorders of flora in the intestinal tract

Irritable bowel syndrome is generally the result of the combined action of psychological factors and the body's stress response. Many patients may be affected by genetic, environmental, psychological, or social factors, leading to gastrointestinal changes. The ingredients in the drug are mainly linaclotide. This component belongs to the agonist of guanylate cyclase C. Through the use of drugs, and it can increase the water in the intestine and achieve a lubricating effect on the intestine. In addition, it can also soften the stool and make the stool excretion smooth. It can promote the secretion of intestinal fluid and increase and promote the peristalsis of intestinal smooth muscle, which is conducive to improving constipation symptoms. Especially in peacetime, due to less exercise or diet factors, accompanied by constipation symptoms, the use of this drug for treatment, the effect is relatively apparent. Patients also need to drink more warm water to treat diseases using linaclotide, which can achieve the outcome of a better wet intestinal tract.

What Is The Mechanism Of Action Of Linaclotide
1. The mechanism for treating constipation
Linaclotide activates the GC-C receptor, while the GC-C receptor is a cross-membrane receptor mainly expressed in intestinal epithelial cells. It can mix with an endogenous ligand, bacterial enterotoxin, and synthetic analogs. Increase the concentration of CGMP in the cell, and promote the phosphorylation of the protein kinase II (CGMP-DependentProteinKinase Ⅱ (PKG-Ⅱ) (CGMP-DependentProteinKinaSe Ⅱ). PKG-Ⅱ is a kind of ligand-activated silk/sourcing protein kinase. It is the primary cell receptor of CGMP. It plays a core role in various physiological processes in CGMP. PKG-Ⅱ phosphorylation can regulate cystic fibrosis cross-membrane transmission regulatory factor (CFTR), affecting intestinal epithelial cells' ion steady state. CFTR is a CAMP-activated ATP door-controlled anion selection channel, which expresses on the top surface of the intestinal epithelial cells. It is the primary channel for chloride and bicarbonate ions to enter the intestinal cavity. After CFTR is activated, it will increase the secretion of chloride and bicarbonate ions so that the sodium ion is passively transferred to the extracellular due to ion gradient, which also prompts the molecular water permeability to passively share with the extracellular, which will lead to an increase in the intestinal liquid. Accelerate gastrointestinal migration, thereby increasing the frequency of stool.

2. The mechanism for treating abdominal pain
Linaclotide can adjust intestinal sensitivity after activating the receptor, and the activation of GC-C can improve the content of cyclo pensions in the cell. When the content of the CGMP internal cells increases, the outer pump that can be mediated by multi-drug-resistant protein (MRP) 4 or 5 can be transferred to the outside of the cell. The elevation of extracellular CGMP concentration can inhibit the excitement of the primary sensory nerves of the intestine and reduce the release of neurotransmitters, thereby suppressing the transmission of pain and impulse and pain sensitivity. It can partially activate GC-C to improve the content of extracellular CGMP, improve the VH of patients with IBS-C, increase the pain threshold, and then relieve abdominal pain. In addition, the peripheral nerve has a marrow and medullary-free sheath fiber, glutamate receptors are present, and ionic glutamate receptors also participate in forming pain allergies. Studies have found that extracellular CGMP can inhibit the response to ionic glutamic acid receptors. Linaclotide may relieve pain by increasing the concentration of CGMP in the cycle and through nerve pain.

What Are The Side Effects Of Linaclotide
1. The treatment of API linaclotide intestinal excitement syndrome Common gastrointestinal reactions: diarrhea, abdominal pain, gastrointestinal demodulation, abdominal distension, viral enteritis, and headache.

2. Treatment of chronic specialty constipation Frequently standard: diarrhea, abdominal pain, gastrointestinal flatulence, abdominal distension, upper respiratory tract infection, sinusitis, occasional indigestion, stool incontinence, viral gastroenteritis, rectal bleeding, and Urticaria.

Factory
1. Xi'an Sonwu Biotech Co., Ltd has its factory to produce, manufacture and store the products, so have adequate Stock. Xi'an Sonwu has a well-ordered, clean, and tidy production department. Under Xi'an Sonwu, researchers can continuously develop high-quality new products.
2. Xi'an Sonwu has strict requirements on personnel allocation from production and testing to sales. To ensure that each product is escorted, rigorous data support and after-sales service are provided.

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Besides guaranteeing the product, the other most important thing is customers can receive the goods smoothly. So, Xi'an Sonwu supplies all kinds of couriers according to different needs.

FAQ
1) Constipation of intestinal excitement syndrome:
The recommended dose is 290 mcg/time, one day/time, and take an empty stomach at least 30 minutes before the day's first meal.
2) Chronic unique constipation:
The recommended dose is 145 mcg/time, one day/time, and take an empty stomach at least 30 minutes before the day's first meal.
If you want to know a linaclotide supplier, you can contact Xi'an Sonwu. Click the email then you get high-quality linaclotide powder.
Email: sales@sonwu.com

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